A Further Example Showing Efficiency of a Modeling Method Based on the Theory of Dynamic Systems in Pharmacokinetics
Published on: 25th January, 2017
OCLC Number/Unique Identifier: 7317655701
Aims: To present a further example showing an efficiency of a modeling method based on the theory of dynamic systems in pharmacokinetics.
Study design:The goals of the current study were twofold: to present (1) a further example showing efficiency of a modeling method based on the theory of dynamic systems in pharmacokinetics, an to perform (2) a next step in tutoring the use of computational and modeling tools from the theory of dynamic systems in pharmacokinetics.
The data available in the study by Plusquellec et al. published in the October Issue of the Journal Medical Engineering & Physics were used to exemplify the method considered here. For modeling purpose an advanced mathematical modeling method was employed. Modeling was performed using the computer program named CTDB described in the study by Dedík et al. published in September 2007 issue of the Journal Diabetes Research and Clinical Practice.
Main outcome: Modeling results revealed that computational and modeling tools from the theory of dynamic systems can be successfully used in the development of a mathematical model of such a complicated process as is a multiple sites discontinuous gastrointestinal absorption.
Brain washing systems and other circulating factors in some neurological condition like Parkinson (Pd) and vascular and diabetic dementia: How dynamics- saturation of clearance can act on toxic molecule?
Published on: 24th January, 2020
OCLC Number/Unique Identifier: 8527419991
Observing the epidemiology of some neurodegenerative disease is interesting to verify some similarity and also related advanced or non-advanced countries and related diet habits. There are relationship between this conditions and diet habits? Some neurological condition related neuro-degeneration can be related to a complex dynamic system like the glymphatic system and the brain vascular clearance. Failure in this system seem related to aggravates of some condition like PD or vascular or diabetic dementia. (Animal model). But what happen if this dynamic system is saturated? A deep investigation related the specific role in CNS make possible to search new innovative strategies. The social economic cost for the neurodegenerative disease is the right tool to new research.
Finite-time thermodynamics: Realizability domains of thermodynamic systems and P. Salamon’s problem of efficiency corresponding to maximum power output of the system
Published on: 16th October, 2018
The paper analyses performance boundaries of systems converting the heat energy into the mechanical or separation work. Authors approach this problem from the view-point of the finite-time thermodynamics. Using thermodynamic balance equations, authors provide the algorithm for calculation of realizability domain for such systems. The paper shows that the performance of these systems is the upper bounded function of the heat flux, assuming that heat and mass transfer coefficients are given. Authors present sufficient conditions under which the efficiency (specific heat flux per unit of the useful flux) of the system does not depend on kinetic coefficients when operating in the maximum performance mode. The paper shows how to use these conditions to optimally choose the separation order for multicomponent distillation.
Pandemic as the second stage of the extinction of our civilization
Published on: 4th October, 2022
In the twentieth century, the works of W. Wien, M. Planck and A. Einstein. Lord Rayleigh, Sh. Bose, L. Landau, M. Weinstein, Yu. Chukova and P. Landsberg [1-5] created a new science – quantum thermodynamics, which formulated the law of the efficiency of conversion of electromagnetic radiation into other types of energy for isothermal processes in open thermodynamic systems. This efficiency is of the greatest interest since the whole living world is a huge factory of isothermal processes.
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