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Outcome of Patients Presenting with Peripartum Cardiomyopathy in a Tertiary Care Center of Nepal

Published on: 29th May, 2024

Purpose: Peripartum cardiomyopathy is a rare life-threatening cardiomyopathy of unknown etiology with significant maternal morbidity and mortality. It causes heart failure due to left ventricular systolic dysfunction with or without left ventricular dilatation in the last month of pregnancy up to 5 months postpartum in previously healthy women. We aimed to determine short-term outcomes of peripartum cardiomyopathy clinically as well as in terms of left ventricular systolic function and to study the clinical profile and associated risk factors.Patients and methods: A prospective observational study was carried out in the Department of Cardiology of Manmohan Cardiothoracic Vascular and Transplant Center, Institute of Medicine, Kathmandu, Nepal, from July 2018 to January 2022. All the patients with peripartum cardiomyopathy who presented to the department of cardiology were enrolled in the study and re-evaluated with echocardiography at 6 months.Results: A total of 68 women met the inclusion criteria. The mean age was 28.38 ± 5.5 years (range 19 to 44 years). The most common clinical presentation was dyspnea followed by lower limb edema. Six (8.8%) patients presented during the last month of pregnancy whereas 62 (91.2%) patients presented in the postpartum period. The mean left ventricular ejection fraction on presentation was 30.01 ± 8.54. A full recovery was observed among 60.29% at 6 months. The mortality rate was 4.41%.Conclusion: Timely diagnosis and management of peripartum cardiomyopathy with standard therapy for heart failure leads to better recovery of left ventricular systolic function.
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A Retrospective Analysis of Maternal Mortality in a Tertiary Care Centre at District Level

Published on: 23rd May, 2024

Background: Maternal mortality is a very sensitive indicator of our health system and services. Epidemiological data about maternal mortality is a vital requirement in every setting not only to design interventional programs but also to identify gaps in the existing structures, to reduce the ratio favorably. This study was an attempt to shed light on the mortality rate in our hospital, to analyze the epidemiological aspects, causes of maternal mortality, and types of delay, and to suggest recommendations for improvement. Methods: A retrospective study was done at a tertiary care center at the district level from January 2022 to December 2022. Demographic data and details of selected parameters were obtained from maternal death review forms and case records. Data analyzed and presented.Results: The majority of the maternal deaths could be attributed to direct obstetric causes like Eclampsia (29.41%), Pre-eclampsia (20.59%), and anemia (20.59%) followed by hemorrhage (14.71%), and septicemia (11.76%). Medical conditions contributing to death included liver disorders (5.8%), COVID-19 infection (5.8%), and cardiac disorders (2.9%). Conclusion: It is evident that the maternal mortality ratio is significantly high, with a majority of the deaths occurring due to avoidable causes. Leading contributory factors were due to delay in seeking help or delay in referral. High-risk cases must be identified at the earliest and referred to higher centers for management from the first trimester itself. Generating awareness among the common public and counseling the gravidas and their caretakers throughout pregnancy is equally important to prevent maternal mortality and near-miss cases.
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Investigate the Effect of Coating Concentration and Coating Thickness on the Anti-microbial Properties of Polycarbonate Sheet

Published on: 29th May, 2024

This paper investigates the effect of coating concentration (ppm), and coating thickness (µm) on the anti-microbial properties of polycarbonate sheets using a variety of anti-microbial agents (Cu-infused Mg(OH)2, Mg(OH)2, Cu(OH)2, MgO, CuCl2.2H2O, and ZnO). In addition, a complete analysis was performed for all agents to rank the best agent in terms of the highest anti-microbial performance against E. coli K-12 MG1655 in two time intervals (4 and 24 hours). The coating concentration (ppm) was found to be a significant factor in the anti-microbial characteristics for Cu-infused Mg(OH)2, Mg(OH)2, Cu(OH)2, MgO, CuCl2.2H2O, and ZnO (p = 0.004, p < 0.0001, p < 0.0001, p = 0.0297, p = 0.0011, and p = 0.0130 respectively). The coating thickness (µm), on the other hand, was found to be a major contributor to the anti-microbial properties of Cu-infused Mg(OH)2, Mg(OH)2, Cu(OH)2, MgO, and CuCl2.2H2O (p < 0.0001, p = 0.0004, p = 0.0011, p = 0.0310, and p < 0.0001 respectively). The analysis determined that the coating did not influence the anti-microbial properties of ZnO. The interaction between the coating concentration (ppm), and the coating thickness (µm) was found to be a significant factor for Cu-infused Mg(OH)2, Cu(OH)2, MgO, CuCl2.2H2O, and ZnO (p < 0.0001, p = 0.0001, p = 0.0004, p < 0.0001, and p < 0.0001 respectively), however, this was not a significant factor for Mg(OH)2.Highlights•    The anti-microbial activity of the inorganic material is dependent on the particle shape and size.•    Particles with sharp edges will provide additional physical injuries to the microorganisms.•    Smaller particle size will provide higher surface area therefore better interaction with microorganisms.•    The coating concentration and coating thickness will be crucial to the anti-microbial activity.•    The thermal embossing techniques demonstrate good adhesion to the surface.
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A Rare Symptomatic Case of Heterozygous Cerebro-Tendinous Xanthomatosis (CTX) Treated with Urso-Deoxycholic Acid (UDCA): With Mini Review

Published on: 27th May, 2024

Cerebrotendinous Xanthamatosis (CTX) is a rare autosomal recessive disorder caused by a mutation in the CYP27A1 gene leading to impaired metabolism of cholesterol and accumulation of cholestenol and the cholesterol in various tissues such as the brain, eyes, lungs and bones and reduced formation of cheno-deoxycholic acid (CDCA). The clinical presentation is diverse, starting in the early neonatal period and progressing till adulthood unless treated early. A common neurological manifestation is a spino-cerebellar ataxia followed by spastic paraparesis. Tendon xanthoma is a classical finding that usually helps in clinching the diagnosis but may not be present in all cases. Brain MRI also reveals characteristic abnormalities with cerebellar atrophy and hyper-intensities in the dentate nucleus and surrounding cerebellar white matter on T1weighted images. It is a rare cause of treatable ataxia in young individuals. Treatment is by replacement by CDCA or Urso-deoxycholic acid (UDCA). Supplemented with statins these individuals also have premature atherosclerosis causing death due to athero-sclerotic coronary artery disease. Here a rare case of symptomatic heterologous CYP27A1 mutation is reported with syndrome of spino-cerebellar ataxia treated with UDCA.
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Agro-morphological Growth Response of Acha (FONIO) (Digitaria exilis and Digitaria iburua [Kippist] Stapf.) Exposed to Colchicine: Germination, Plant Height and Leaf Number

Published on: 30th May, 2024

Acha (Fonio) Digitaria sp. is a valuable cereal crop widely cultivated in several African countries. The genetic improvement of Acha through induced mutagenesis has gained attention for enhancing desirable traits. Colchicine, a mitotic inhibitor, is commonly used to induce polyploidy, which can lead to alterations in plant characteristics. This study aimed to investigate the effects of colchicine treatment on germination, plant height, and leaf count of two Acha species. Seeds from two Digitaria species, Digitaria exilis, and Digitaria iburua, were subjected to colchicine treatment using different concentrations (0.05, 0.10, 0.15, and 0.20g/dL). The control group was treated with distilled water. Germination rates were assessed by measuring the percentage of seeds that successfully sprouted. Plant height and leaf number were measured at maturity and analyzed using ANOVA on SPSS Version 26. The results indicated that colchicine treatment significantly affected germination, plant height, and leaf number in both Digitaria species. Germination rates varied depending on the concentration, with lower germination observed at higher concentrations (70.70% and 74.3% for 0.20g/dL treatment in both species). In terms of plant height, colchicine-treated Acha plants exhibited significant differences compared to the control group. The majority of treated plants showed increased growth (57.00 cm to 60.70 cm in D. exilis and 114.10 to 122.40 cm in D. iburua) compared to the control. Variability in plant height was observed among the treated plants, suggesting that colchicine-induced polyploidy had varying effects on height across different genotypes. Similarly, the number of leaves was affected by colchicine treatment. Treated plants exhibited an increase in leaf number (56.70 to 60.7 for D exilis and 32.60 to 36.30 for D. iburua), compared to the control group (49.7 and 29.7 respectively). This variability suggests that colchicine-induced polyploidy may have influenced leaf development and growth patterns in Acha. Colchicine treatment had significant effects on germination, plant height, and leaf count in both varieties of Acha. The results suggest that colchicine-induced polyploidy can alter these plant characteristics. These findings provide insights into the potential use of colchicine treatment for inducing desirable traits in Acha through polyploidization, which may have implications for crop improvement and breeding programs. Further research is warranted to explore the underlying mechanisms and assess the impact of these alterations on overall agronomic performance and yield potential.
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Agro-morphological Growth Response of Acha (Fonio) (Digitaria Exilis and Digitaria Iburua [Kippist] Stapf.) Exposed to Colchicine: Leaf Length, Leaf Width and Leaf Area Index

Published on: 3rd June, 2024

The present study investigated the effects of colchicine treatment on leaf length, leaf width, and leaf area index (LAI) in two species of Acha (fonio), namely Digitaria exilis and Digitaria iburua. Colchicine, a potent mitotic inhibitor, has been widely used to induce polyploidy and in studying the effects of genome duplication on various morphological traits. This study aimed to explore if colchicine treatment could alter the leaf morphology of the two Acha species. Seeds of the two species were treated with colchicine solution at various concentrations (0.05, 0.10, 0.15, and 0.20 g/dL), while a control group was maintained without any treatment. Leaf length and width were measured using a meter rule, and LAI was calculated by multiplying the leaf length and leaf width with the constant for both species. Statistical analysis was performed using the Analysis of Variance on SPSS to determine significant differences between treated and control groups. The results showed that colchicine treatment had a significant effect on leaf morphology in both Acha species. Leaf length and width increased significantly in response to colchicine treatment, with the degree of increase depending on the concentration. Moreover, the LAI also exhibited a significant increase in treated plants compared to the control group. Colchicine concentration level of 0.10 g/dLproduced the best results that can be exploited to enhance the morphological characteristics of both Acha species. The findings suggest that colchicine-induced polyploidy can enhance leaf growth and overall leaf area in Acha plants, leading to potential implications for agricultural productivity and yield improvement. Further studies are needed to elucidate the underlying mechanisms and long-term effects of colchicine-induced polyploidy on other growth parameters, reproductive traits, and yield in Acha. Understanding the genetic and physiological changes associated with polyploidy in Acha species will contribute to the development of improved breeding strategies and cultivation practices for this important cereal crop.
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Epidemioclinical Profile of Inflammatory Ringworm in Children at the Koulikoro Reference Health Centre (Csref)

Published on: 10th June, 2024

Introduction: Inflammatory or suppurative ringworm is a rare form of dermatophyte damage to the hair scalp. The aim is to describe the epidemioclinical profile of inflammatory ringworm in children at the Koulikoro Reference Health Centre (Csref).Methodology: This was a 12-month descriptive cross-sectional study of all cases of Kerions diagnosed in children at the Koulikoro Csref.Results: Over 12 months, 25 cases were recorded among 1,200 consulting patients, representing a hospital frequency of 2%.Males were 22 and females three, with a sex ratio of 7.33. The mean age was 7 years, ranging from 2 to 13 years.Conclusion: Celse kerions appear to be common in school-age boys, and contact with domestic animals is described in the majority of cases. Further work is needed to describe the fungi responsible and the risk factors.
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Accidents at Waste Storage Facilities: Methods of Struggle with the Consequences of Accidents

Published on: 17th June, 2024

The article deals with such issues as storage of industrial waste, causes, examples and prevention of accidents, NGO operation and reclamation, and methods of dealing with the consequences of accidents. When storing industrial waste in large volumes, various complications arise, including accidents in waste storage facilities. The article provides examples of accidents for specific objects and analyzes their causes and consequences. The methods of dealing with the consequences of accidents and their prevention are considered. The materials of the article can help specialists improve the design and operation of waste storage facilities.
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Evaluation of Performance Research Nuclear Reactors' Steady-state and Kinetic Model Analyses

Published on: 18th June, 2024

The mainstays of nuclear substance radiation and isotopic synthesis are nuclear-powered power plants, however effective safety evaluation is made tougher by the complicated construction topologies and physical connection effects. This work proposes a multiphysics-linked technique for evaluating both the kinetic and steady-state behaviors of the MPRR and LVR-15 laboratory reactors. To represent complicated member geometries, homogenized assembling sections are generated using two-dimensional whole-core computational simulations. It is discovered that the steady-state findings and the so-called Monte Carl solution comparisons correspond quite nicely. The greatest assemble power mistakes for LVR-15 and MPRR are 6.49%/10%, and the highest command rod value mistakes are 31 pcm/136 pcm, and the mistakes are 377 pcm/383 pcm, accordingly. Meanwhile, the study is done on transitory procedures, such as reactivity-initiated disasters and exposed loss-of-flow mishaps. Both units' modeling findings show plausible adverse feedback events. Furthermore, it is shown that the two reactors' accident-related behaviors are comparable though having different core architectures since they employ the exact same kinds of water as a fluid. The technique for studying nuclear power plant kinetics known as Multi-Physics Simulation (MPM) is explained. Drawing on many research and verification efforts conducted at Politecnico di Milan, Italy, MPM is shown to be a valuable instrument for managing reactors' security and oversight. It may be viewed as a holistic analytical tool that is implemented during the reactor architecture design phase. The capacity to concurrently answer the interrelated equations that control the many physical processes taking place in a nuclear plant inside the same simulated setting is a core characteristic of MPM.
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A Study on Nuclear Physics Fission using the Relativistic Time-dependent Density Functional Theory Approach

Published on: 18th June, 2024

A thorough knowledge of the stationary characteristics of the nuclei of atoms, their stimulation wavelengths, how they react to outside factors, and how they disintegrate is the aim of nuclear structural science. Although achieving these objectives within just one structure is difficult and prevents the existence of a nuclear "standard model," it is evident that radioactive Density Functional Theory (DFT) offers perhaps the broadest variety of applications to date. We attempt to place DFT in a larger perspective in this study by making frequent allusions to electrical DFT. We also provide a brief overview of the numerous uses and an explanation of the connections between beginning techniques and Useful Field Concepts (EFTs) in particular. The article tries to promote collaborations with different scientific fields while being published from a subjective and perhaps biased point of view.
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Effectiveness of an Ayurvedic Gel for Tooth Pain Relief Due to Dental Caries: A Randomized Controlled Trial

Published on: 19th June, 2024

Aim: To evaluate the effectiveness of an ayurvedic gel in tooth pain reduction due to dental caries. Materials and methods: This in vivo cross-over design study enrolled adults with at least one tooth with caries and a symptom of pain after the application of an ice stimulus. Two hundred patients were screened and eligible patients were enrolled in the study. Forty-five subjects completed washout phases before each recall visit. During each recall visit, subjects evaluated pain relief following an ice bar stimulus and one random finger-tip application of a treatment i.e. Ayurveda Herbal gel containing clove oil, camphor, and menthol (Ayurveda Herbal Gel Group), and two control formulations: a gel without active ingredients and commercial olive oil as a surrogate of home remedy. At each assessment, subjects used a stopwatch to record the onset of pain relief and tooth pain using visual analog scores (VAS), dental pain scores (DPS), and relief from tooth pain by dental pain relief scores (DPRS). After each treatment, subjects recorded their satisfaction with the provided treatment using a four-point satisfaction index. Data were tabulated and statistical analysis was performed with (ANCOVA) and two-way ANOVA with a p - value of 0.05 considered statistically significant. Results: Forty-five subjects (28 males and 17 females) completed the entire study without any adverse events. Application of the Ayurveda gel resulted in a significantly faster onset of pain relief (2.47 min) in comparison to the onset of pain relief after 4 minutes recorded with the controls (p < 0.05). Subjects reported lower VAS and DPS scores over the study period of evaluation when using the Ayurveda gel compared to the application of each control formulation. Subjects also reported greater relief of pain and greater satisfaction after the application of the Ayurveda gel as compared to the controls. Conclusion: Significantly better tooth pain relief from caries was observed from an Ayurveda Herbal gel than from controls.
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Percutaneous Closure of Post-myocardial Infarction Ventricular Septal Rupture-experience From a Resource-limited Setup From Eastern Part of India

Published on: 20th June, 2024

Background: Post-infarction ventricular septal rupture (VSR) is a rare but lethal mechanical complication of an acute myocardial infarction (AMI). It results in 90% - 95% mortality within two months of diagnosis without any kind of intervention. Given high surgical mortality, transcatheter closure has emerged as a potential strategy as an alternative to high-risk surgical closure. Indian data on percutaneous device closure of post-AMI-VSR is limited hence we report our resource-limited single-centre experience with different kinds of occluder devices for closure of post-AMI VSR.Methods and results: In this single-centre, retrospective, cohort study, patients who underwent transcatheter closure of post-MI VSR between 2018 and 2024 at Health World hospitals, in Durgapur, West Bengal, were included. The primary outcome was a mortality rate of 30 days. The study population was eleven primary cases of post-MI VSR. The mean age of the population was 61 years. The majority of the patients had anterior wall MI (54.5%) and the remaining had inferior wall MI.  Different kinds of devices (ASO, PostMI VSD device, Konar MFO) were used to close VSR. Successful closure was performed in 9 patients (81%) with minimal residual shunt in 2 patients. Out of 9 cases 3 patients expired, one was lost to follow up and the rest are doing well at 30 days follow-up. Conclusion: Transcatheter closure of PMIVSRs can be performed with different kinds of devices with high technical success, relatively low procedural complication rates, and 30 days survival even in a resource-limited setup as an alternative to high-risk surgical closure.
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Exploring Dermatofunctional Perspectives beyond Aesthetics: An Integrative Literature Review

Published on: 21st June, 2024

Introduction: Dermatofunctional Physiotherapy is an area of physiotherapeutic specialty that aims to promote, prevent, and treat integumentary injuries. However, this field of action is usually erroneously limited to aesthetic and cosmetic procedures. However, the scope of Physical Therapy goes beyond aesthetic procedures. Objective: To identify the scope of dermatofunctional physiotherapy beyond aesthetics. Methodology: This is an integrative literature review with the objective of summarizing and exploring the proposed theme. For this, the PRISMA guidelines were used, as well as the PICOT strategy for a better delineation of the research question and research theme. Results and discussions: It was observed that the role of the physiotherapist in this field is directly related to aesthetics, which is one of the most prosperous segments within the health area, due to the great demand for aesthetic procedures. Among the main resources evidenced in this study, lymphatic drainage, electrothermophototherapeutic resources, myofascial release, and manual techniques were observed. Final considerations: The area of physical therapy is not exclusively dedicated to the aesthetic environment, it was observed that this specialty acts strongly in the promotion, and prevention of rehabilitation of patients with metabolic, integumentary, and musculoskeletal alterations, in addition to promoting and preventing diseases related to obesity, scars, geloid edema, flaccidity, and other integumentary dysfunctions.
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Effects of Physical Therapy in The Postoperative Period of Plastic Surgery: An Integrative Review

Published on: 21st June, 2024

Introduction: The practice of plastic surgery began in the field of reconstructive surgery, in an attempt to recover the functionality of some area of ​​the body or give it a more natural appearance. In this sense, the role of the physical therapist is recommended in various aesthetic surgeries that, through physical therapy resources and techniques, promote tissue healing, reduce the appearance of adhesions, and reduce or eliminate pain, bruises, and edema. Objective: to identify the effects of physical therapy in the postoperative period of plastic surgery. Methodology: This is an integrative literature review, in which there will be a review of articles related to the study of the effects of physical therapy assistance applied to the postoperative period of plastic surgery. Articles related to the proposed theme were included, published between 2011 and 2024, available in full, without language restriction; in addition to theses, dissertations, and monographs. Exclusion criteria were literature review articles, articles or abstracts that had been published in conference proceedings; as well as letters from editors and preprints. Results and discussions: it can show that physiotherapy in the postoperative period of plastic surgery is essential in reducing recovery time, reducing edema, improving the healing process, and preventing the risk of complications in the postoperative period. The main physiotherapeutic resources and techniques were: lymphatic drainage, ultrasound, radiofrequency, laser, and high frequency. Regarding plastic surgeries, the most frequent in the literature were: abdominoplasty, blepharoplasty, rhytidectomy, and liposuction. Final considerations: Dermatofunctional physiotherapy is of paramount importance in the postoperative period of plastic surgery. It is essential in reducing recovery time and reducing the risks arising from surgery.
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Efficacy of Sequential Applications of Pendimethalin 500 EC (Pendimight®) and Oxyfluofen 240 EC (Harris®) for Weed Control in Direct Seeded Onion (Allium cepa L.) in Sudan

Published on: 26th June, 2024

A field study was carried out to evaluate the efficacy of pendimethalin 500 EC (trade name: Pendimight®) and oxyfluorfen 240 EC (trade name: Harris®) to control weeds in direct-seeded onion (Allium cepa L.). Pendimethalin and oxyfluorfen were applied solely at reduced rates (1.35 and 0.17 kg a.i. ha-1), and at the recommended rates (1.8 and 0.25 kg a.i. ha-1) as pre-and post-emergence herbicides, respectively. Both herbicides were also applied sequentially at the same doses. Ten weeks after sowing (WAS), the application of pendimethalin alone provided better weed control (62% - 65%) than oxyfluorfen alone (33% - 43%) when they were applied at the lower and recommended rates, respectively. Sequential applications of the two herbicides as pre-and post-emergence herbicides, outperformed applications of the two herbicides alone, and resulted in the best weed control (79% to 85%), lowest weed dry weight (18.35 to 35.60 g.m-2), significantly increased plant height and the number of leaves per plant, and resulted in a ten-fold higher onion yield (24.64 to 26.37 t. ha-1) compared with the Un-weeded control (2.27 t. ha-1). There were no significant differences observed between the treatments on the emergence (%) of onion seeds and the survival of onion seedlings. Sequential applications of pendimethalin and oxyfluorfen is a promising techniques for weed control in direct-seeded onions in Sudan.
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MRI-based Tumor Habitat Analysis for Treatment Evaluation of Radiotherapy on Esophageal Cancer

Published on: 24th June, 2024

Introduction: We aim to evaluate the performance of pre-treatment MRI-based habitat imaging to segment tumor micro-environment and its potential to identify patients with esophageal cancer who can achieve pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT).Material and methods: A total of 18 patients with locally advanced esophageal cancer (LAEC) were recruited into this retrospective study. All patients underwent MRI before nCRT and surgery using a 3.0 T scanner (Ingenia 3.0 CX, Philips Healthcare). A series of MR sequences including T2-weighted (T2), diffusion-weighted imaging (DWI), and Contrast Enhance-T1 weighted (CE-T1) were performed. A clustering algorithm using a two-stage hierarchical approach groups MRI voxels into separate clusters based on their similarity. The t-test and receiver operating characteristic (ROC) analysis were used to evaluate the predictive effect of pCR on habitat imaging results. Cross-validation of 18 folds is used to test the accuracy of predictions.Results: A total of 9 habitats were identified based on structural and physiologic features. The predictive performance of habitat imaging based on these habitat volume fractions (VFs) was evaluated. Students’ t-tests identified 2 habitats as good classifiers for pCR and non-pCR patients. ROC analysis shows that the best classifier had the highest AUC (0.82) with an average prediction accuracy of 77.78%.Conclusion: We demonstrate that MRI-based tumor habitat imaging has great potential for predicting treatment response in LAEC. Spatialized habitat imaging results can also be used to identify tumor non-responsive sub-regions for the design of focused boost treatment to potentially improve nCRT efficacy.
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Utilizing Smartphone ECG for Early Detection and Management of Ischemic Heart Disease: A Case Report

Published on: 24th June, 2024

Ischemic Heart Disease (IHD) remains a significant cause of morbidity and mortality worldwide. We present a case report of a 54-year-old individual presenting with symptoms suggestive of IHD, including palpitations and chest heaviness. Utilizing a Spandan device at home, the patient detected anteroseptal and lateral wall ischemia, prompting consultation with a cardiologist. Subsequent diagnostic evaluations revealed Left Ventricular Hypertrophy (LVH), concentric LVH, regional wall motion abnormality, and Grade I diastolic dysfunction. Hypertension and dyslipidemia were identified as prominent risk factors, with additional findings of carotid artery disease. Management strategies included antihypertensive medications, lipid-lowering therapy, and lifestyle modifications. This case underscores the complexity of diagnosing and managing IHD, highlighting the importance of comprehensive assessment and multidisciplinary care in optimizing patient outcomes.
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Phytochemical Compounds and the Antifungal Activity of Centaurium pulchellum Ethanol Extracts in Iraq

Published on: 25th June, 2024

The current study included a variety of phytochemical substances that were extracted from Centaurium pulchellum and showed a wide range of medicinal properties from the plant's reproductive and vegetative parts against the pathogenic fungus Aspergillus flavus. The vegetative and reproductive components of Centaurium pulchellum were subjected to (GC-MS) analysis for phytochemical study. The data indicated that fungal activity was the highest. Four extract concentrations of 5, 10, 15, and 20 mg/ml were utilized in the investigation, and the diameter of the colonies measured at each concentration was 90.00, 36.00, 28.00, 18.00, and 0.00 mm, respectively.Nine bioactive phytochemical compounds were found in Centaurium pulchellum's vegetative and reproductive portions, according to GC-MS analysis of the chemicals. Another study reported phytochemical substances that: 1-H-Imidazole-2-carboxaldehyde, 1-methyl-;Acetaminophen; n-Hexadecanoic acid; Mercaptoacetic acid, 2TMS derivative; 1.2,3-Dimethyl-5-(trifluoromethyl)-1,4-benzenediol #; Mercaptoethanol, 2TMS derivative-; Bis-(3,5,5-trimethylhexyl) phthalate Tetrakis(trimethylsilyl) orthosilicate #;- 1.1-Isopropoxy-3,3,3-trimethyl-1-[(trimethylsilyl)oxy]disiloxanyl tris(trimethylsilyl) orthosilicate #.
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Physicians’ Anxiety Post-COVID Pandemic: A Cross-Sectional Study

Published on: 27th June, 2024

The psychological burden of physicians has been the focus of many researchers since the 1950s, and some papers have found a high prevalence of anxiety and depressive disorders among medical staff. Recent studies have shown that the coronavirus pandemic didn’t go easy on healthcare workers. The fact that it has been three years since the outbreak, has motivated our study. Which aims to evaluate the intensity of anxiety among medical personnel and the risk factors that could be incriminated post-COVID pandemic and if the level of anxiety is back to normal. This is a cross-sectional study, carried out with a survey split into 2 parts sociodemographic and work-related data, and the French version of the Hamilton anxiety scale, Statistical analysis was performed using Jamovi et Microsoft Excel. About half of the 116 physicians in our study had no anxiety (55.2%), while 21.6% had mild anxiety, 10.3% had moderate anxiety, and 12.9% had severe anxiety. The identified risk factors for anxiety were female gender, personal and family history of anxiety disorder, doing night shifts, and being a general practitioner. The anxiety rate of physicians is back to normal post-COVID pandemic. But we shouldn’t stop there. The mental health status of medical personnel depends on several of the factors listed above. Determining them would imply a call for the implementation of preventive measures for anxiety and depressive disorders among physicians. Because taking care of physicians is taking care of patients.
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Descriptive Study of the Urinary Tract Infections in Patients Admitted in the Cardiology Ward of Afghan Momand Medical Complex

Published on: 28th June, 2024

Urinary Tract Infection (UTI) is very common in our community most specifically in married females with numerous antecedent risk factors. The aim of the study was to find out about the current risk factors and clinical profile of urinary tract infections in patients admitted to the cardiology ward of Afghan Momand Medical Complex for various purposes.It was a cross-sectional descriptive hospital-based study including both male and female patients visiting the Afghan Momand Medical Complex from January 2022 to June 2022. Of all 960 patients, 202 (21%) patients had urinary tract infections with gender distribution as 69 (34.2%) males and 133 (65.8%) females. In fact, 33 (16.3%) patients with urinary tract infections were single while the rest 169 (83.7%) patients were married. In addition, regarding clinical profile, the following clinic was respectively more prevalent: Dysuria in 120 (59.4%) patients, flank pain in 73 (36.1%) patients, urine frequency in 67 (33.1%) patients, urgency in 36 (17.8%) patients, fever in 24 (11.8%) patients, and nausea and vomiting in 19 (9.4%) patients. Moreover, the following risk factors were respectively the most common ones: Diabetes mellitus 86 (42.5%), pregnancy 30 (14.9%), stones 15 (7.4%), 10 (4.9%) devices, 10 (4.9%) prostatic hyperplasia, and 4 (2%) anatomical anomalies.Urinary tract infection is a common disease in the admitted patients in Afghan Momand Medical Complex specifically being more common in females and early 20s of the age. In fact, diabetes, pregnancy, and kidney stones were the leading associated factors with UTI. Moreover, dysuria, bladder emptying irritative symptoms, and abdominal pain were the most prevalent clinical profile of the patients. Special attention should be paid to infectious diseases in cardiac patients since infection itself is a stress and a threat to such patients and authorities should design special measures to prevent UTI in the general population to avoid a sum of burden on the health system.
Cite this ArticleCrossMarkPublonsHarvard Library HOLLISGrowKudosResearchGateBase SearchOAI PMHAcademic MicrosoftScilitSemantic ScholarUniversite de ParisUW LibrariesSJSU King LibrarySJSU King LibraryNUS LibraryMcGillDET KGL BIBLiOTEKJCU DiscoveryUniversidad De LimaWorldCatVU on WorldCat

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